CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonucleotide Reductase, subunit A
Functional Family

Enzyme Information

1.14.13.236
Toluene 4-monooxygenase.
based on mapping to UniProt Q00460
Toluene + NADH + O(2) = 4-methylphenol + NAD(+) + H(2)O.
-!- This bacterial enzyme belongs to a family of soluble diiron hydroxylases that includes toluene-, benzene-, xylene- and methane monooxygenases, phenol hydroxylases, and alkene epoxidases. -!- The enzyme comprises a four-component complex that includes a hydroxylase, NADH-ferredoxin oxidoreductase, a Rieske-type [2Fe-2S] ferredoxin, and an effector protein.

UniProtKB Entries (1)

Q00459
TMOD_PSEME
Pseudomonas mendocina
Toluene-4-monooxygenase system, effector component

PDB Structure

PDB 3Q3O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystallographic analysis of active site contributions to regiospecificity in the diiron enzyme toluene 4-monooxygenase.
Bailey, L.J., Acheson, J.F., McCoy, J.G., Elsen, N.L., Phillips, G.N., Fox, B.G.
Biochemistry