CATH Domain 3q3cA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1040	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
	1.10.1040.10	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

Domain Context

CATH Clusters

Superfamily	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family	3-hydroxyisobutyrate dehydrogenase

Enzyme Information

1.1.1.387

L-serine 3-dehydrogenase (NAD(+)).

based on mapping to UniProt Q9I5I6

L-serine + NAD(+) = 2-aminoacetaldehyde + CO(2) + NADH.

-!- The enzyme, purified from the bacterium Pseudomonas aeruginosa, also shows activity with L-threonine (cf. EC 1.1.1.103). -!- The enzyme has only very low activity with NADP(+) (cf. EC 1.1.1.276).

UniProtKB Entries (1)

Q9I5I6

SERDH_PSEAE

Pseudomonas aeruginosa PAO1

NAD-dependent L-serine dehydrogenase

PDB Structure

PDB	3Q3C
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Biochemical and Structural Studies of Uncharacterized Protein PA0743 from Pseudomonas aeruginosa Revealed NAD+-dependent L-Serine Dehydrogenase. Tchigvintsev, A., Singer, A., Brown, G., Flick, R., Evdokimova, E., Tan, K., Gonzalez, C.F., Savchenko, A., Yakunin, A.F. J.Biol.Chem.