CATH Domain 3q3cA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.1.1.387

L-serine 3-dehydrogenase (NAD(+)).

based on mapping to UniProt Q9I5I6

L-serine + NAD(+) = 2-aminoacetaldehyde + CO(2) + NADH.

-!- The enzyme, purified from the bacterium Pseudomonas aeruginosa, also shows activity with L-threonine (cf. EC 1.1.1.103). -!- The enzyme has only very low activity with NADP(+) (cf. EC 1.1.1.276).

UniProtKB Entries (1)

Q9I5I6

SERDH_PSEAE

Pseudomonas aeruginosa PAO1

NAD-dependent L-serine dehydrogenase

PDB Structure

PDB	3Q3C
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Biochemical and Structural Studies of Uncharacterized Protein PA0743 from Pseudomonas aeruginosa Revealed NAD+-dependent L-Serine Dehydrogenase. Tchigvintsev, A., Singer, A., Brown, G., Flick, R., Evdokimova, E., Tan, K., Gonzalez, C.F., Savchenko, A., Yakunin, A.F. J.Biol.Chem.