CATH Classification

Domain Context

CATH Clusters

Superfamily Glutaredoxin
Functional Family Glutathione S-transferase omega-1

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt Q9H4Y5
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.
1.20.4.2
Methylarsonate reductase.
based on mapping to UniProt Q9H4Y5
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O.
-!- The product, methylarsonite, is biologically methylated by EC 2.1.1.137 to form cacodylic acid. -!- Formerly EC 1.97.1.7.
1.8.5.1
Glutathione dehydrogenase (ascorbate).
based on mapping to UniProt Q9H4Y5
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.

UniProtKB Entries (1)

Q9H4Y5
GSTO2_HUMAN
Homo sapiens
Glutathione S-transferase omega-2

PDB Structure

PDB 3Q19
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases.
Zhou, H., Brock, J., Liu, D., Board, P.G., Oakley, A.J.
J.Mol.Biol.