CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.750.220
Functional Family

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt Q859P9
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q859P9
RPOLV_BPN4
Escherichia virus N4
Virion DNA-directed RNA polymerase

PDB Structure

PDB 3Q0A
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides.
Gleghorn, M.L., Davydova, E.K., Basu, R., Rothman-Denes, L.B., Murakami, K.S.
Proc.Natl.Acad.Sci.USA