CATH Classification

Domain Context

CATH Clusters

Superfamily Protein prenylyltransferase
Functional Family Geranylgeranyl transferase type-2 subunit alpha

Enzyme Information

2.5.1.60
Protein geranylgeranyltransferase type II.
based on mapping to UniProt Q08602
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl- protein + diphosphate.
-!- This enzyme, along with EC 2.5.1.58 and EC 2.5.1.59, constitutes the protein prenyltransferase family of enzymes. -!- Attaches geranylgeranyl groups to two C-terminal cysteines in Ras- related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in XXCC, XCXC and CCXX motifs. -!- Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP). -!- Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion.

UniProtKB Entries (1)

Q08603
PGTB2_RAT
Rattus norvegicus
Geranylgeranyl transferase type-2 subunit beta

PDB Structure

PDB 3PZ2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Guided Development of Selective RabGGTase Inhibitors.
Bon, R.S., Guo, Z., Stigter, E.A., Wetzel, S., Menninger, S., Wolf, A., Choidas, A., Alexandrov, K., Blankenfeldt, W., Goody, R.S., Waldmann, H.
Angew.Chem.Int.Ed.Engl.