CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC

Enzyme Information

1.5.-.-
Acting on the CH-NH group of donors.
based on mapping to UniProt Q8ZD36
2.1.1.61
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase.
based on mapping to UniProt Q8ZD36
S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2- thiouridylate.
-!- Specific for the terminal methyl group of 5-methylaminomethyl-2- thiouridylate.

UniProtKB Entries (1)

Q8ZD36
MNMC_YERPE
Yersinia pestis
TRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC

PDB Structure

PDB 3PVC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC.
Kim, J., Almo, S.C.
Bmc Struct.Biol.