CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.58.1560
Functional Family

Enzyme Information

2.3.3.9
Malate synthase.
based on mapping to UniProt D4GTL2
Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA.
-!- The enzyme catalyzes the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. -!- Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO(2). -!- Formerly EC 4.1.3.2.

UniProtKB Entries (1)

D4GTL2
ACEB_HALVD
Haloferax volcanii DS2
Malate synthase

PDB Structure

PDB 3PUG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of a halophilic archaeal malate synthase from Haloferax volcanii and comparisons with isoforms A and G.
Bracken, C.D., Neighbor, A.M., Lamlenn, K.K., Thomas, G.C., Schubert, H.L., Whitby, F.G., Howard, B.R.
Bmc Struct.Biol.