CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.50.150
Functional Family DNA-directed RNA polymerase subunit beta

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P08518
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P40422
RPAB4_YEAST
Saccharomyces cerevisiae S288C
DNA-directed RNA polymerases I, II, and III subunit RPABC4

PDB Structure

PDB 3PO3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of RNA polymerase II backtracking, arrest and reactivation.
Cheung, A.C., Cramer, P.
Nature