CATH Classification

Domain Context

CATH Clusters

Superfamily DNA polymerase, thumb domain
Functional Family DNA polymerase lambda

Enzyme Information

4.2.99.-
Other carbon-oxygen lyases.
based on mapping to UniProt Q9UGP5
2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q9UGP5
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9UGP5
DPOLL_HUMAN
Homo sapiens
DNA polymerase lambda

PDB Structure

PDB 3PNC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Replication infidelity via a mismatch with Watson-Crick geometry.
Bebenek, K., Pedersen, L.C., Kunkel, T.A.
Proc.Natl.Acad.Sci.USA