CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q06187
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q06187
BTK_HUMAN
Homo sapiens
Tyrosine-protein kinase BTK

PDB Structure

PDB 3PJ1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Kuglstatter, A., Wong, A., Tsing, S., Lee, S.W., Lou, Y., Villasenor, A.G., Bradshaw, J.M., Shaw, D., Barnett, J.W., Browner, M.F.
Protein Sci.