CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Casein kinase II subunit alpha

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P68400
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P68400
CSK21_HUMAN
Homo sapiens
Casein kinase II subunit alpha

PDB Structure

PDB 3PE2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer.
Battistutta, R., Cozza, G., Pierre, F., Papinutto, E., Lolli, G., Sarno, S., O'Brien, S.E., Siddiqui-Jain, A., Haddach, M., Anderes, K., Ryckman, D.M., Meggio, F., Pinna, L.A.
Biochemistry