CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family tyrosine aminotransferase

Enzyme Information

2.6.1.5
Tyrosine transaminase.
based on mapping to UniProt Q8QZR1
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.
-!- L-phenylalanine can act instead of L-tyrosine. -!- The mitochondrial enzyme may be identical with EC 2.6.1.1. -!- The three isoenzymic forms are interconverted by EC 3.4.22.32 and EC 3.4.22.33. -!- The enzyme can also catalyze the final step in the methionine-salvage pathway of Klebsiella pneumoniae.

UniProtKB Entries (1)

Q8QZR1
ATTY_MOUSE
Mus musculus
Tyrosine aminotransferase

PDB Structure

PDB 3PDX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Tyrosine aminotransferase: biochemical and structural properties and molecular dynamics simulations.
Mehere, P., Han, Q., Lemkul, J.A., Vavricka, C.J., Robinson, H., Bevan, D.R., Li, J.
Protein Cell