CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.450.330
Functional Family Peptidoglycan D,D-transpeptidase FtsI

Enzyme Information

3.4.16.4
Serine-type D-Ala-D-Ala carboxypeptidase.
based on mapping to UniProt Q51504
Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.
-!- A group of bacterial enzymes, membrane-bound. -!- Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme. -!- Distinct from EC 3.4.17.14. -!- Belongs to peptidase families S11, S12 and S13.

UniProtKB Entries (1)

Q51504
Q51504_PSEAI
Pseudomonas aeruginosa
Peptidoglycan D,D-transpeptidase FtsI

PDB Structure

PDB 3PBO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.
Han, S., Zaniewski, R.P., Marr, E.S., Lacey, B.M., Tomaras, A.P., Evdokimov, A., Miller, J.R., Shanmugasundaram, V.
Proc.Natl.Acad.Sci.USA