CATH Classification

Domain Context

CATH Clusters

Superfamily Zn peptidases
Functional Family Glutaminyl-peptide cyclotransferase

Enzyme Information

2.3.2.5
Glutaminyl-peptide cyclotransferase.
based on mapping to UniProt Q16769
L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3).
-!- Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues. -!- The enzyme from papaya also acts on glutaminyl-tRNA.

UniProtKB Entries (1)

Q16769
QPCT_HUMAN
Homo sapiens
Glutaminyl-peptide cyclotransferase

PDB Structure

PDB 3PBB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding
Huang, K.F., Liaw, S.S., Huang, W.L., Chia, C.Y., Lo, Y.C., Chen, Y.L., Wang, A.H.J.
J.Biol.Chem.