CATH Domain 3pb4X00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.630	Aminopeptidase
	3.40.630.10	Zn peptidases

Domain Context

CATH Clusters

Superfamily	Zn peptidases
Functional Family	glutaminyl-peptide cyclotransferase-like protein

Enzyme Information

2.3.2.5

Glutaminyl-peptide cyclotransferase.

based on mapping to UniProt Q9NXS2

L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3).

-!- Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues. -!- The enzyme from papaya also acts on glutaminyl-tRNA.

UniProtKB Entries (1)

Q9NXS2

QPCTL_HUMAN

Homo sapiens

Glutaminyl-peptide cyclotransferase-like protein

PDB Structure

PDB	3PB4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding Huang, K.F., Liaw, S.S., Huang, W.L., Chia, C.Y., Lo, Y.C., Chen, Y.L., Wang, A.H.J. J.Biol.Chem.