CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.50 | Alpha/alpha barrel |
|
1.50.10 | Glycosyltransferase |
|
1.50.10.130 | Terpene synthase, N-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Terpene synthase, N-terminal domain |
| Functional Family |
Enzyme Information
| 4.2.3.17 |
Taxadiene synthase.
based on mapping to UniProt Q41594
Geranylgeranyl diphosphate = taxa-4,11-diene + diphosphate.
-!- This is the committed step in the biosynthesis of the diterpenoid antineoplastic drug Taxol (paclitaxel). -!- The cyclization involves a 1,5-hydride shift.
|
UniProtKB Entries (1)
| Q41594 |
TASY_TAXBR
Taxus brevifolia
Taxadiene synthase
|
PDB Structure
| PDB | 3P5R |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis.
Nature
|