CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha-helical ferredoxin
Functional Family Succinate dehydrogenase iron-sulfur subunit

Enzyme Information

1.3.5.1
Succinate dehydrogenase (quinone).
based on mapping to UniProt P0AC47
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.

UniProtKB Entries (1)

P0AC47
FRDB_ECOLI
Escherichia coli K-12
Fumarate reductase iron-sulfur subunit

PDB Structure

PDB 3P4R
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Geometric restraint drives on- and off-pathway catalysis by the Escherichia coli menaquinol:fumarate reductase.
Tomasiak, T.M., Archuleta, T.L., Andrell, J., Luna-Chavez, C., Davis, T.A., Sarwar, M., Ham, A.J., McDonald, W.H., Yankovskaya, V., Stern, H.A., Johnston, J.N., Maklashina, E., Cecchini, G., Iverson, T.M.
J.Biol.Chem.