CATH Classification

Domain Context

CATH Clusters

Superfamily succinate dehydrogenase protein domain
Functional Family Fumarate reductase flavoprotein subunit

Enzyme Information

1.3.5.4
Fumarate reductase (quinol).
based on mapping to UniProt P00363
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. -!- The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, to which it is closely related.

UniProtKB Entries (1)

P0AC47
FRDB_ECOLI
Escherichia coli K-12
Fumarate reductase iron-sulfur subunit

PDB Structure

PDB 3P4R
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Geometric restraint drives on- and off-pathway catalysis by the Escherichia coli menaquinol:fumarate reductase.
Tomasiak, T.M., Archuleta, T.L., Andrell, J., Luna-Chavez, C., Davis, T.A., Sarwar, M., Ham, A.J., McDonald, W.H., Yankovskaya, V., Stern, H.A., Johnston, J.N., Maklashina, E., Cecchini, G., Iverson, T.M.
J.Biol.Chem.