CATH Classification

Domain Context

CATH Clusters

Superfamily POLO box domain
Functional Family Serine/threonine-protein kinase PLK

Enzyme Information
Polo kinase.
based on mapping to UniProt P53350
ATP + a protein = ADP + a phosphoprotein.
-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Serine/threonine-protein kinase PLK1

PDB Structure

PDB 3P37
External Links
Primary Citation
From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1
Sledz, P., Stubbs, C.J., Lang, S., Yang, Y.Q., McKenzie, G.J., Venkitaraman, A.R., Hyvonen, M., Abell, C.