CATH Classification

Domain Context

CATH Clusters

Superfamily Phospholipase A2 domain
Functional Family

Enzyme Information

3.1.1.4
Phospholipase A(2).
based on mapping to UniProt P00592
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
-!- Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position.

UniProtKB Entries (1)

P00592
PA21B_PIG
Sus scrofa
Phospholipase A2, major isoenzyme

PDB Structure

PDB 3P2P
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Enhanced activity and altered specificity of phospholipase A2 by deletion of a surface loop.
Kuipers, O.P., Thunnissen, M.M., de Geus, P., Dijkstra, B.W., Drenth, J., Verheij, H.M., de Haas, G.H.
Science