CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family

Enzyme Information

2.1.1.180
16S rRNA (adenine(1408)-N(1))-methyltransferase.
based on mapping to UniProt A8C927
S-adenosyl-L-methionine + adenine(1408) in 16S rRNA = S-adenosyl-L- homocysteine + N(1)-methyladenine(1408) in 16S rRNA.
-!- The enzyme provides a panaminoglycoside-resistant nature through interference with the binding of aminoglycosides toward the A site of 16S rRNA through N(1)-methylation at position adenine(1408).

UniProtKB Entries (1)

A8C927
NPMA_ECOLX
Escherichia coli
16S rRNA (adenine(1408)-N(1))-methyltransferase

PDB Structure

PDB 3P2K
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for the methylation of A1408 in 16S rRNA by a panaminoglycoside resistance methyltransferase NpmA from a clinical isolate and analysis of the NpmA interactions with the 30S ribosomal subunit.
Husain, N., Obranic, S., Koscinski, L., Seetharaman, J., Babic, F., Bujnicki, J.M., Maravic-Vlahovicek, G., Sivaraman, J.
Nucleic Acids Res.