CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O75460
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
3.1.26.-
Endoribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt O75460

UniProtKB Entries (1)

O75460
ERN1_HUMAN
Homo sapiens
Serine/threonine-protein kinase/endoribonuclease IRE1

PDB Structure

PDB 3P23
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response.
Ali, M.M., Bagratuni, T., Davenport, E.L., Nowak, P.R., Silva-Santisteban, M.C., Hardcastle, A., McAndrews, C., Rowlands, M.G., Morgan, G.J., Aherne, W., Collins, I., Davies, F.E., Pearl, L.H.
Embo J.