CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.220.160
Functional Family Histone-lysine N-methyltransferase SMYD3

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q9H7B4
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q9H7B4
SMYD3_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase SMYD3

PDB Structure

PDB 3OXF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding.
Xu, S., Wu, J., Sun, B., Zhong, C., Ding, J.
Nucleic Acids Res.