CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.47 | Peroxisomal Thiolase; Chain A, domain 1 |
|
3.40.47.10 | Thiolase/Chalcone synthase |
Domain Context
CATH Clusters
| Superfamily | 3.40.47.10 |
| Functional Family | Chalcone synthase 1 |
Enzyme Information
| 2.3.1.217 |
Curcumin synthase.
based on mapping to UniProt C0SVZ6
Feruloyl-CoA + feruloylacetyl-CoA + H(2)O = 2 CoA + curcumin + CO(2).
-!- A polyketide synthase from the plant Curcuma longa (turmeric). -!- Three isoforms exist, CURS1, CURS2 and CURS3. -!- While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate, CURS3 can accept 4-coumaroyl-CoA equally well (see EC 2.3.1.219).
|
UniProtKB Entries (1)
| C0SVZ6 |
CURS1_CURLO
Curcuma longa
Curcumin synthase 1
|
PDB Structure
| PDB | 3OV3 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A hydrophobic cavity discovered in a curcumin synthase facilitates utilization of a beta-keto acid as an extender substrate for the atypical type III polyleteide synthase
To be Published
|