CATH Classification

Domain Context

CATH Clusters

Superfamily 2.30.30.140
Functional Family

Enzyme Information

3.4.23.-
Aspartic endopeptidases.
based on mapping to UniProt P14350
2.7.7.49
RNA-directed DNA polymerase.
based on mapping to UniProt P14350
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
3.1.26.4
Ribonuclease H.
based on mapping to UniProt P14350
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.
2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P14350
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
3.1.-.-
Acting on ester bonds.
based on mapping to UniProt P14350
2.7.7.-
Nucleotidyltransferases.
based on mapping to UniProt P14350

UniProtKB Entries (1)

P14350
POL_FOAMV
Human spumaretrovirus
Pro-Pol polyprotein

PDB Structure

PDB 3OS1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The mechanism of retroviral integration from X-ray structures of its key intermediates
Maertens, G.N., Hare, S., Cherepanov, P.
Nature