CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family renin

Enzyme Information

3.4.23.15
Renin.
based on mapping to UniProt P00797
Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.
-!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.15 and EC 3.4.99.19.

UniProtKB Entries (1)

P00797
RENI_HUMAN
Homo sapiens
Renin

PDB Structure

PDB 3OQK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors.
Scheiper, B., Matter, H., Steinhagen, H., Stilz, U., Bocskei, Z., Fleury, V., McCort, G.
Bioorg.Med.Chem.Lett.