CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P0AD64
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P0AD64
BLA1_KLEPN
Klebsiella pneumoniae
Beta-lactamase SHV-1

PDB Structure

PDB 3OPH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase.
Sampson, J.M., Ke, W., Bethel, C.R., Pagadala, S.R., Nottingham, M.D., Bonomo, R.A., Buynak, J.D., van den Akker, F.
Antimicrob.Agents Chemother.