CATH Classification

Domain Context

CATH Clusters

Superfamily SET domain
Functional Family Histone-lysine N-methyltransferase

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q9NR48
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q9NR48
ASH1L_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase ASH1L

PDB Structure

PDB 3OPE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism
An, S., Yeo, K.J., Jeon, Y.H., Song, J.
J.Biol.Chem.