CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q99986
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q99986
VRK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase VRK1

PDB Structure

PDB 3OP5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.
Counago, R.M., Allerston, C.K., Savitsky, P., Azevedo, H., Godoi, P.H., Wells, C.I., Mascarello, A., de Souza Gama, F.H., Massirer, K.B., Zuercher, W.J., Guimaraes, C.R.W., Gileadi, O.
Sci Rep