CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.970
Functional Family Transketolase isoform 1

Enzyme Information

2.2.1.1
Transketolase.
based on mapping to UniProt P29401
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.
-!- Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO(2) and R-CHOH-CO-CH(2)OH. -!- The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor.

UniProtKB Entries (1)

P29401
TKT_HUMAN
Homo sapiens
Transketolase

PDB Structure

PDB 3OOY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of human Transketolase (TKT)
Krojer, T., Krysztofinska, E., Guo, K., Pilka, E., Kochan, G., Chaikuad, A., Vollmar, M., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Kavanagh, K., Oppermann, U.
To be Published