CATH Domain 3olhA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.250	Oxidized Rhodanese; domain 1
	3.40.250.10	Rhodanese-like domain

Domain Context

CATH Clusters

Superfamily	Rhodanese-like domain
Functional Family	Sulfurtransferase

Enzyme Information

2.8.1.2

3-mercaptopyruvate sulfurtransferase.

based on mapping to UniProt P25325

3-mercaptopyruvate + reduced thioredoxin = pyruvate + hydrogen sulfide + oxidized thioredoxin.

-!- The enzyme catalyzes a transsulfuration reaction from 3-mercaptopyruvate to an internal cysteine residue. -!- In the presence of a dithiol such as reduced thioredoxin or dihydrolipoate, the sulfanyl sulfur is released as hydrogen sulfide. -!- The enzyme participates in a sulfur relay process that leads to the 2-thiolation of some tRNAs and to protein urmylation by transferring sulfur between the NFS1 cysteine desulfurase (EC 2.8.1.7) and the MOCS3 sulfurtransferase (EC 2.8.1.11).

UniProtKB Entries (1)

P25325

THTM_HUMAN

Homo sapiens

3-mercaptopyruvate sulfurtransferase

PDB Structure

PDB	3OLH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Human 3-Mercaptopyruvate Sulfurtransferase Karlberg, T., Collins, R., Arrowsmith, C.H., Berglund, H., Bountra, C., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Kotenyova, T., Kouznetsova, E., Moche, M., Nordlund, P., Nyman, T., Persson, C., Sehic, A., Schutz, P., Siponen, M.I., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Schuler, H. To be Published