CATH Classification

Domain Context

CATH Clusters

Superfamily Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Enzyme Information

2.7.7.60
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.
based on mapping to UniProt P9WKG9
CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
-!- ATP or UTP can replace CTP, but both are less effective. -!- GTP and TTP are not substrates. -!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

UniProtKB Entries (1)

P9WKG9
ISPD_MYCTU
Mycobacterium tuberculosis H37Rv
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

PDB Structure

PDB 3OKR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Mycobacterium tuberculosis 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD): an antitubercular drug target
Sacchettini, J.C., Reddy, M.C.M., Bruning, J.B., Thurman, C.
To be Published