CATH Classification

Domain Context

CATH Clusters

Superfamily Glycogen Phosphorylase B;
Functional Family Alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase

Enzyme Information

2.4.1.346
Phosphatidyl-myo-inositol dimannoside synthase.
based on mapping to UniProt Q8NNK8
(1) GDP-alpha-D-mannose + 2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo- inositol = GDP + 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo- inositol. (2) GDP-alpha-D-mannose + 2-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl- 1D-myo-inositol = GDP + 2-O-(6-O-acyl-alpha-D-mannosyl)-6-O-alpha-D- mannosyl-1-phosphatidyl-1D-myo-inositol.
-!- The enzyme, found in Corynebacteriales, is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs). -!- Formerly EC 2.4.1.57.

UniProtKB Entries (1)

Q8NNK8
PIMB_CORGL
Corynebacterium glutamicum ATCC 13032
GDP-mannose-dependent monoacylated alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase

PDB Structure

PDB 3OKC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB'.
Batt, S.M., Jabeen, T., Mishra, A.K., Veerapen, N., Krumbach, K., Eggeling, L., Besra, G.S., Futterer, K.
J.Biol.Chem.