CATH Classification

Domain Context

CATH Clusters

Superfamily Translation factors
Functional Family NADPH--cytochrome P450 reductase

Enzyme Information

1.6.2.4
NADPH--hemoprotein reductase.
based on mapping to UniProt P00388
NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.
-!- This enzyme catalyzes the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P450 monooxygenases (e.g. EC 1.14.14.1) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. -!- It also reduces cytochrome b5 and cytochrome c. -!- The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.

UniProtKB Entries (1)

P00388
NCPR_RAT
Rattus norvegicus
NADPH--cytochrome P450 reductase

PDB Structure

PDB 3OJX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor Binding.
Xia, C., Hamdane, D., Shen, A.L., Choi, V., Kasper, C.B., Pearl, N.M., Zhang, H., Im, S.C., Waskell, L., Kim, J.J.
J.Biol.Chem.