CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Enoyl-[acyl-carrier-protein] reductase [NADH]

Enzyme Information

1.3.1.9
Enoyl-[acyl-carrier-protein] reductase (NADH).
based on mapping to UniProt P54616
An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADH.
-!- The enzyme catalyzes an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier- protein] derivatives of the elongating fatty acid moiety. -!- The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18. -!- The FAS-I enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons.

UniProtKB Entries (1)

P54616
FABI_BACSU
Bacillus subtilis subsp. subtilis str. 168
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

PDB Structure

PDB 3OIG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of Enoyl-ACP Reductases I (FabI) and III (FabL) from B. subtilis
Kim, K.-H., Ha, B.H., Kim, S.J., Hong, S.K., Hwang, K.Y., Kim, E.E.
J.Mol.Biol.