CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidyl-prolyl cis-trans isomerase A

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P62937
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P62937
PPIA_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase A

PDB Structure

PDB 3ODI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin).
Kuglstatter, A., Mueller, F., Kusznir, E., Gsell, B., Stihle, M., Thoma, R., Benz, J., Aspeslet, L., Freitag, D., Hennig, M.
Acta Crystallogr.,Sect.D