CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Non-specific serine/threonine protein kinase

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P31749
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P31749
AKT1_HUMAN
Homo sapiens
RAC-alpha serine/threonine-protein kinase

PDB Structure

PDB 3O96
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of human AKT1 with an allosteric inhibitor reveals a new mode of kinase inhibition.
Wu, W.I., Voegtli, W.C., Sturgis, H.L., Dizon, F.P., Vigers, G.P., Brandhuber, B.J.
Plos One