CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q13451
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q13451
FKBP5_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase FKBP5

PDB Structure

PDB 3O5J
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90.
Bracher, A., Kozany, C., Thost, A.K., Hausch, F.
Acta Crystallogr.,Sect.D