CATH Classification

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family Tyrosine-protein phosphatase non-receptor type 5

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P35236
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P35236
PTN7_HUMAN
Homo sapiens
Tyrosine-protein phosphatase non-receptor type 7

PDB Structure

PDB 3O4S
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Visualizing active-site dynamics in single crystals of HePTP: opening of the WPD loop involves coordinated movement of the E loop.
Critton, D.A., Tautz, L., Page, R.
J.Mol.Biol.