CATH Classification

Domain Context

CATH Clusters

Superfamily Glycogen Phosphorylase B;
Functional Family Glycogen [starch] synthase

Enzyme Information

2.4.1.11
Glycogen(starch) synthase.
based on mapping to UniProt P27472
UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha- D-glucosyl)(n+1).
-!- The description (official name) varies according to the source of the enzyme and the nature of its synthetic product. -!- Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. -!- The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186. -!- A similar enzyme utilizes ADP-glucose (cf. EC 2.4.1.21).

UniProtKB Entries (1)

P27472
GYS2_YEAST
Saccharomyces cerevisiae S288C
Glycogen [starch] synthase isoform 2

PDB Structure

PDB 3O3C
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for glucose-6-phosphate activation of glycogen synthase.
Baskaran, S., Roach, P.J., Depaoli-Roach, A.A., Hurley, T.D.
Proc.Natl.Acad.Sci.USA