CATH Domain 3o2qE01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.2300	Response regulator

Domain Context

CATH Clusters

Superfamily	3.40.50.2300
Functional Family	RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Enzyme Information

3.1.3.16

Protein-serine/threonine phosphatase.

based on mapping to UniProt Q9NP77

[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.

-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

UniProtKB Entries (1)

Q92797

SYMPK_HUMAN

Homo sapiens

Symplekin

PDB Structure

PDB	3O2Q
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Xiang, K., Nagaike, T., Xiang, S., Kilic, T., Beh, M.M., Manley, J.L., Tong, L. Nature

Network disruptions