CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-kinase, accessory domain (PIK)
Functional Family Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Enzyme Information

2.7.1.153
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt P48736
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P48736
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P48736
PK3CG_HUMAN
Homo sapiens
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

PDB Structure

PDB 3NZS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase.
Staben, S.T., Heffron, T.P., Sutherlin, D.P., Bhat, S.R., Castanedo, G.M., Chuckowree, I.S., Dotson, J., Folkes, A.J., Friedman, L.S., Lee, L., Lesnick, J., Lewis, C., Murray, J.M., Nonomiya, J., Olivero, A.G., Plise, E., Pang, J., Prior, W.W., Salphati, L., Rouge, L., Sampath, D., Tsui, V., Wan, N.C., Wang, S., Wiesmann, C., Wu, P., Zhu, B.Y.
Bioorg.Med.Chem.Lett.