CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.1160 | Carbamate kinase |
|
3.40.1160.10 | Acetylglutamate kinase-like |
Domain Context
CATH Clusters
| Superfamily | Acetylglutamate kinase-like |
| Functional Family | Uridylate kinase |
Enzyme Information
| 2.7.4.22 |
UMP kinase.
based on mapping to UniProt P9WHK5
ATP + UMP = ADP + UDP.
-!- Strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme EC 2.7.4.14 for the same purpose. -!- Subject of feedback regulation, being inhibited by UTP and activated by GTP.
|
UniProtKB Entries (1)
| P9WHK5 |
PYRH_MYCTU
Mycobacterium tuberculosis H37Rv
Uridylate kinase
|
PDB Structure
| PDB | 3NWY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation.
Nucleic Acids Res.
|