CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.1.1.369
D-chiro-inositol 1-dehydrogenase.
based on mapping to UniProt P26935
1D-chiro-inositol + NAD(+) = 2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH.
-!- The enzyme, found in the bacterium Bacillus subtilis, also catalyzes the reaction of EC 1.1.1.18 and can also use D-glucose and D-xylose. -!- It shows trace activity with D-ribose and D-fructose. -!- It is part of a myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA. -!- Formerly EC 1.1.1.n6.
1.1.1.18
Inositol 2-dehydrogenase.
based on mapping to UniProt P26935
Myo-inositol + NAD(+) = 2,4,6/3,5-pentahydroxycyclohexanone + NADH.

UniProtKB Entries (1)

P26935
IOLG_BACSU
Bacillus subtilis subsp. subtilis str. 168
Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase

PDB Structure

PDB 3NT5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural investigation of myo-inositol dehydrogenase from Bacillus subtilis: implications for catalytic mechanism and inositol dehydrogenase subfamily classification.
van Straaten, K.E., Zheng, H., Palmer, D.R., Sanders, D.A.
Biochem.J.