CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1280.10
Functional Family

Enzyme Information

2.1.1.230
23S rRNA (adenosine(1067)-2'-O)-methyltransferase.
based on mapping to UniProt P52391
S-adenosyl-L-methionine + adenosine(1067) in 23S rRNA = S-adenosyl-L- homocysteine + 2'-O-methyladenosine(1067) in 23S rRNA.
-!- The methylase that is responsible for autoimmunity in the thiostrepton producer Streptomyces azureus, renders ribosomes completely resistant to thiostrepton. -!- Formerly EC 2.1.1.66.

UniProtKB Entries (1)

P52391
NSHR_STRAS
Streptomyces actuosus
23S rRNA (adenosine(1067)-2'-O)-methyltransferase

PDB Structure

PDB 3NK6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Nosiheptide-Resistance Methyltransferase of Streptomyces actuosus
Yang, H., Wang, Z., Shen, Y., Wang, P., Jia, X., Zhao, L., Zhou, P., Gong, R., Li, Z., Yang, Y., Chen, D., Murchie, A.I.H., Xu, Y.
Biochemistry