CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Adenosylhomocysteinase

Enzyme Information

3.3.1.1
Adenosylhomocysteinase.
based on mapping to UniProt P23526
S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.
-!- The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4.

UniProtKB Entries (1)

P23526
SAHH_HUMAN
Homo sapiens
Adenosylhomocysteinase

PDB Structure

PDB 3NJ4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues.
Lee, K.M., Choi, W.J., Lee, Y., Lee, H.J., Zhao, L.X., Lee, H.W., Park, J.G., Kim, H.O., Hwang, K.Y., Heo, Y.S., Choi, S., Jeong, L.S.
J.Med.Chem.