CATH Domain 3ngxA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

3.5.4.9	Methenyltetrahydrofolate cyclohydrolase. based on mapping to UniProt Q05213 5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.
1.5.1.5	Methylenetetrahydrofolate dehydrogenase (NADP(+)). based on mapping to UniProt Q05213 5,10-methylenetetrahydrofolate + NADP(+) = 5,10- methenyltetrahydrofolate + NADPH.

UniProtKB Entries (1)

FOLD_THEAC

Thermoplasma acidophilum DSM 1728

Bifunctional protein FolD

PDB Structure

PDB	3NGX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase from Thermoplasma acidophilum Lee, W.H., Sung, M.W., Kim, J.H., Kim, Y.K., Han, A., Hwang, K.Y. Biochem.Biophys.Res.Commun.