CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1170.60
Functional Family DNA polymerase iota

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q9UNA4
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9UNA4
POLI_HUMAN
Homo sapiens
DNA polymerase iota

PDB Structure

PDB 3NGD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for Proficient Incorporation of dTTP Opposite O6-Methylguanine by Human DNA Polymerase {iota}.
Pence, M.G., Choi, J.Y., Egli, M., Guengerich, F.P.
J.Biol.Chem.