CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.20
Functional Family D-alanine--D-alanine ligase

Enzyme Information

6.3.2.4
D-alanine--D-alanine ligase.
based on mapping to UniProt Q5HEB7
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.
-!- Involved with EC 6.3.2.7 or EC 6.3.2.13, EC 6.3.2.8, EC 6.3.2.9 and EC 6.3.2.10 in the synthesis of a cell-wall peptide.

UniProtKB Entries (1)

Q5HEB7
DDL_STAAC
Staphylococcus aureus subsp. aureus COL
D-alanine--D-alanine ligase

PDB Structure

PDB 3N8D
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular basis of vancomycin dependence in VanA-type Staphylococcus aureus VRSA-9.
Meziane-Cherif, D., Saul, F.A., Moubareck, C., Weber, P., Haouz, A., Courvalin, P., Perichon, B.
J.Bacteriol.